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Ativan (lorazepam),is a nearly white powder almost insoluble in water. Each Ativan (lorazepam)
tablet, to be taken orally, contains 0.5 mg, 1 mg, or 2 mg of lorazepam. The
inactive ingredients present are lactose monohydrate, magnesium stearate,
microcrystalline cellulose, polacriline potassium.
Ativan (lorazepam) is indicated for the management of anxiety disorders or for
the short-term relief of the symptoms of anxiety or anxiety associated with
depressive symptoms. Anxiety or tension associated with the stress of everyday
life usually does not require treatment with an anxiolytic.
The effectiveness of Ativan (lorazepam) in long-term use, that is, more than 4
months, has not been assessed by systematic clinical studies. The physician
should periodically reassess the usefulness of the drug for the individual patient.
Most adverse reactions to benzodiazepines, including CNS effects and
respiratory depression, are dose dependent, with more severe effects occurring
with high doses.
In a sample of about 3500 patients treated for anxiety, the most frequent adverse
reaction to Ativan (lorazepam) was sedation (15.9%), followed by dizziness
(6.9%), weakness (4.2%), and unsteadiness (3.4%). The incidence of sedation
and unsteadiness increased with age.
Other adverse reactions to benzodiazepines, including lorazepam are fatigue,
drowsiness, amnesia, memory impairment, confusion, disorientation,
depression, unmasking of depression, disinhibition, euphoria, suicidal
ideation/attempt, ataxia, asthenia, extrapyramidal symptoms,
convulsions/seizures tremor, vertigo, eye-function/visual disturbance (including
diplopia and blurred vision), dysarthria/slurred speech, change in libido,
impotence, decreased orgasm; headache, coma; respiratory depression, apnea,
worsening of sleep apnea, worsening of obstructive pulmonary disease;
gastrointestinal symptoms including nausea, change in appetite, constipation,
jaundice, increase in bilirubin, increase in liver transaminases, increase in
alkaline phosphatase; hypersensitivity reactions, anaphylactic/oid reactions;
dermatological symptoms, allergic skin reactions, alopecia; SIADH,
hyponatremia; thrombocytopenia, agranulocytosis, pancytopenia; hypothermia;
and autonomic manifestations.
Paradoxical reactions, including anxiety, excitation, agitation, hostility,
aggression, rage, sleep disturbances/insomnia, sexual arousal, and
hallucinations may occur. Small decreases in blood pressure and hypotension
may occur but are usually not clinically significant, probably being related to the
relief of anxiety produced by Ativan (lorazepam).
Ativan (lorazepam) is contraindicated in patients with
– hypersensitivity to benzodiazepines or to any components of the formulation.
– acute narrow-angle glaucoma.
Pre-existing depression may emerge or worsen during use of benzodiazepines
including lorazepam. Ativan (lorazepam) is not recommended for use in patients
with a primary depressive disorder or psychosis.
Use of benzodiazepines, including lorazepam, both used alone and in
combination with other CNS depressants, may lead to potentially fatal respiratory
Use of benzodiazepines, including lorazepam, may lead to physical and
As with all patients on CNS-depressant drugs, patients receiving lorazepam
should be warned not to operate dangerous machinery or motor vehicles and
that their tolerance for alcohol and other CNS depressants will be diminished.